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KMID : 0368819920310051009
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Journal of the Korean Neuropsychiatr Association
1992 Volume.31 No. 5 p.1009 ~ p.1024
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Cerebral Dysfunction in Two Cases of Meige's Disease
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Abstract
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We report two cases of Meige's disease. One shows complete syndrome with lesions in red nucleus, thalamus and frontal white matter, and the other shows incomplete syndrome with lesions in cerebellar vermis and basal ganglia. Functional
implications
and
their relationship with the pathophysiologic mechanisms of Meige's disease are speculated.
Clinical symptoms which resemble other involuntary movement disorders, site of lesions found by various anatomical studies, and good to fair responses to antipsychotics suggest the dysfunction of dopaminergic system-hyperactivity of dopaminergic
system
induced by yet unidentified mechanisms.
The remarkably high prevalence of depression preceding or following the advent of involuntary hyperkinetic motor symptoms is also of interest.
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KEYWORD
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